The second and third seeds will face off in a mouth-watering last four encounter that is a repeat of the 2012 final, a match which Federer emerged triumphant from.
The pair can barely be separated in a head-to-head match-up, with Federer just having the edge 12-11. The Swiss maestro has also won the last three matches that they have played, with the two most recent victories coming in straight sets.
Both men have been in good form thus far at the All England Club, and Roddick – who lost to Federer in the Wimbledon final three times – feels it is going to be a titanic battle.
“This is a fascinating match-up, with Federer serving as well as he is, and Murray's ability to break,” Roddick told the BBC.
“They have played each other 23 times and their head-to-head record is very close, so they know each other extremely well and they also have two of the highest IQs in the game.
“They will know what has been successful in their wins and what hasn't worked in their defeats. What makes it such a great rivalry is that they both have all the shots – they can both mix up the pace of their shots and come into the net if they need to.”
Roddick believes that the result will come down to which man plays the best on the day.
“It is going to come down to whoever executes their game plan better on the day, and that is where the predicting game becomes tough,” he said.
“I think it is too close to call. If anyone says with any measure of confidence that they truly believe one or the other will go out there and definitely win, they are probably not telling the truth.”
World number one Novak Djokovic faces Richard Gasquet in the second semi-final.