The reigning World Champion had a dismal Saturday at the Italian circuit as he failed to reach the final shootout in qualifying for the first time in his MotoGP career.
Poor pace in FP3 coupled by a fall in FP4 meant he started Q1 on his back-up bike. Confident that he had set a time that would see him progress to Q2, Marquez was sitting in the pits as rivals upped their pace and he found himself missing out on a top-two time needed to progress.
As a result, he will line-up 13th on the Italian GP grid.
But already Valentino Rossi has come out saying those ahead must watch for the Honda rider, a sentiment echoed by Lorenzo.
"We cannot forget Marc and I think he has been a little bit unlucky in the morning and also in the qualifying," Crash.net quotes Lorenzo as having said.
"For sure he has the pace for a much better position than he starts in. If he starts well he can overtake some positions in the first metres and then let's see.
"In the first corner here it's always quite complicated and it's going to be dangerous for everyone. Let's see, I hope that nothing happens."