Leishman’s wife Audrey was placed in an induced coma at an urgent care centre near their Virginia Beach home earlier this week after being diagnosed with pneumonia.
The Australian has informed the Masters committee that he will not be competing at Augusta National this week as he remains with his wife and their two young children.
He issued a short statement which read: “It is with both deep regret and incredible relief I am withdrawing from the Masters tournament this week.
“My wife Audrey has survived a life threatening medical emergency and I have decided to remain by her side with our children.”
Leishman’s wife is expected to recover from her illness, but he is understandably in no frame of mind to be competing in the first major of the year.
The 31-year-old was in contention for the 2013 Masters title before finishing tied for fourth with Tiger Woods, behind his compatriots Jason Day and champion Adam Scott.
His withdrawal this year reduces the field to 97 players, as there are no alternates at Augusta.