The first contest between the two took place in October 1894, and in honour of Saturday’s derby we look back at some of the best matches between the clubs in the modern era.
2012: Premier League, Liverpool 3-0 Everton
Given that Steven Gerrard will make his 701st Liverpool appearance on Saturday it seems only fitting that we begin with a derby in which he showcased his magic.
Everton headed to Anfield full of confidence on this occasion having gone 10 matches unbeaten in the build-up while their hosts had endured three league defeats on the trot.
This too was a milestone match for Gerrard, his 400th Premier League game, and it was the Reds skipper who opened the scoring with a sumptuous lob in the first half.
After the break Luis Suarez demonstrated how there is more to him than just goals, providing two assists for Gerrard as the midfielder complied the first derby hat-trick since Ian Rush scored four in 1982.
The game itself was certainly memorable for the Red half of Merseyside, but it was the Blues who would go on to finish higher up the Premier League standings.
3. 2006 Everton 3-0 Liverpool, Premier League
Under David Moyes Everton were known more for having a miserly defence than for being a lethal attacking unit, but on this occasion they proved to be both.
Tiny Tim Cahill put Everton ahead in the 24th minute, with then-record signing Andy Johnson getting a second after capitalising on an error from Jamie Carragher.
Everton would profit from another Liverpool mistake, this time from goalkeeper Pepe Reina, as Johnson picked up his second, heading home after Reina failed to hang onto a Lee Carsley cross.
It was the first time that the Toffees had scored three goals in a derby since 1966 and was their biggest derby victory in 42 years. To cap it off the win briefly propelled Everton to the top of the table.
2. 2001 Everton 2-3 Liverpool, Premier League
This derby was packed with action from start to finish with plenty of drama to keep neutrals enthralled and Merseysiders on the edge of their seats.
With less than five minutes on the clock Emile Heskey opened the scoring for the Reds before Duncan Ferguson ensured that the two teams would head into the break all square.
The first half may have been intriguing, but the second period was off the charts.
Marcus Babel put Liverpool back in front and Robbie Fowler had a chance to extend the Reds’ lead, but couldn’t find the back of the net from the penalty spot.
Igor Biscan picked up his second yellow to reduce the visitors to ten men and with five minutes remaining Everton looked set to grab a point when David Unsworth converted his penalty chance to draw the Toffees level.
However, there would be late, late drama, with Gary McAllister somehow finding the bottom corner with a curling freekick from a massive 44 yards out in the fourth minute of injury time.
1. 1991 Everton 4-4 Liverpool, FA Cup 5th Round
As if the drama of a league derby isn’t enough, Liverpool and Everton have also faced off in some spicy cup ties. This encounter in February 1991 was certainly one of those.
Having played out a goalless draw at Anfield the two teams headed to Goodison Park for a replay.
The Reds took the lead four times through Peter Beardsley, Ian Rush and John Barnes, but on each occasion the Toffees found a way to get back into the contest. Graeme Sharp provided the first two equalisers before super sub Tony Cottee grabbed a brace of his own.
Barnes’ fantastic goal in extra time looked for all money to be the winner, but Cottee popped up in the 114th minute to secure a replay for the Everton.
Kenny Dalglish resigned two days later and the Toffees would win the second replay 1-0, but their FA Cup adventure was ended by West Ham in the next round.