Madrid beat Schalke 9-2 on aggregate on their way to winning the Champions League for a 10th time last season, but have stumbled recently in La Liga.
Carlo Ancelotti’s men were beaten for a fourth time in 14 games in 2015 at Athletic Bilbao on Saturday to surrender top spot in La Liga to Barcelona for the first time in five months.
“I don’t believe Real Madrid are in a crisis. I hope the media is right that the strikers are not in good form. We will need a little bit of luck as well tomorrow night to get a positive result.
“The game on Saturday was different. It was an away game in Bilbao, who are a very strong team, and they didn’t allow Real Madrid to get into their flow. Tomorrow they play in front of their home fans and I think it will be different.
“I think three weeks ago they were talking about a crisis as well with the Real Madrid team. I don’t expect a team in crisis tomorrow.”
Di Matteo does however believe his side must score first at the Bernabeu on Tuesday if they are to have any chance of progressing.
“We have to score the first goal and if we open the scoring then the match could be interesting for us,” said Di Matteo, who won the Champions League when in charge of Chelsea in 2012.
Madrid’s star front three of Cristiano Ronaldo, Karim Benzema and Gareth Bale have come in for criticism as the goals have dried up in recent weeks.