Pep Guardiola???s men will be bidding to become the first team to claim four consecutive German titles having achieved three consecutively on four separate occasions.
Bayern will start their season a day ahead of the rest of the league when they take on Bruno Labbadia???s six-time winners at the Allianz Arena.
It???s a difficult start for a Hamburg side which has escaped relegation via the play-offs in each of the last two seasons after coming seventh in 2012/13.
DFB Cup winners Wolfsburg, who finished directly behind Bayern in the standings last term, are also at home on the opening weekend as they take on Frankfurt on August 15.
The post-Jurgen Klopp era begins at Borussia Dortmund with new coach Thomas Tuchel???s team facing Borussia Monchengladbach at Signal Iduna Park.
Darmstadt, who were playing in the fifth tier of German football just seven years ago, mark their long-awaited return to the Bundesliga with a home tie against Hannover.
Ingolstadt, who won the 2 Bundesliga last season ahead of Darmstadt and clinched promotion to the top flight for the first time, get under way with a trip to Mainz.
Elsewhere, Werder Bremen play Schalke, Augsburg host Hertha Berlin and Stuttgart ??? another team who narrowly avoided the drop before the summer – are at home to Cologne.
Bayer Leverkusen take on Hoffenheim, now preparing for their seventh season among the elite, in the opening weekend???s other fixture.