Seongnam play Guangzhou at home at Tancheon Sports Complex after finishing second in Group F behind Gamba Osaka, having lost 2-1 to the Japanese side in the final match of Group F.
Guangzhou comfortably won Group H and have looked impressive.
Both teams have both progressed beyond the group phase on more than four occasions including clinching the silverware once.
Seongnam do not have many high profile players as none represented their country in the AFC Asian Cup in January.
The difference is that Guangzhou have a number of Chinese internationals and other overseas players like tournament top-scorer Ricardo Goulart in their squad.
Guangzhou coach Fabio Cannavaro has said that they can’t expect to stroll past Seongnam and if they think the match will be easy they could live to regret it.
Kim Hak-bum's side lost just once out of 11 outings at home in all competitions this season.
Seongnam coach Kim Hak-bum believes that if his side are well prepared and get some of their injured players back they will have every chance to progress further in the tournament
"Guangzhou Evergrande have good players, but it is hard to make a full analysis on them just yet, so I want to have a good preparation for these matches," said Hak-bum.
"I am also hoping to get our injured players back in time for those games as I expect the tournament to be tougher as it progresses," he added.