Jeonbuk Hyundai Motors v Beijing Guoan
After finishing as runners-up in Group E, K-League champions Jeonbuk welcome Group G winners Beijing Guoan to the Jeonju World Cup Stadium.
The home side are enjoying a strong run of form that has seen them win five in a row in all competitions, with a 2-1 victory over Daejeon Citizen on Sunday their most recent success.
The South Korean outfit has been eliminated from the competition at the last 16 stage for the past two seasons, and if they are to avoid another disappointment they will need their in-form strike duo of Lee Dong-gook and Edu to make their mark.
Beijing Guoan didn't end the group stages of the Champions League in the best of form, with a 1-0 defeat to Brisbane Roar in their penultimate game followed by a 1-1 draw with Suwon Samsung Bluewings two weeks ago.
However, the defeat to Brisbane was their only loss in their last five matches in all tournaments, and they head into the match on the back of a 2-0 victory over Liaoning.
Should Gregorio Manzano's side progress to the quarter-finals, it will be the first time in the club's history that they have done so.
Suwon Samsung Bluewings v Kashiwa Reysol
Suwon continue their quest for a third continental title when they welcome Kashiwa Reysol to the Suwon World Cup Stadium. The South Korean club finished second in a tough Group G, beating off the challenge of J-League side Urawa Red Diamonds for a spot in the knockout stages alongside group winners Beijing Guoan.
Seo Jung-won's side are in the midst of an indifferent run of form. While Suwon beat Jeju United 1-0 on Saturday, they had won only one of the five matches that preceded it, having lost to Jeonnam Dragons in the FA Cup and Jeonbuk Hyundai Motors and Daejeon Citizen in the league, while drawing with Beijing Guoan in their final group stage match.
However, Kashiwa's form is even more patchy, with the J-League side without a win in their last four matches in all competition, with Tatsuma Yoshida's side have failed to score in that period.
When the two clubs met in the group stage of the 2013 AFC Champions League, a somewhat bizarre fixture played out, with Kashiwa grabbing a 6-2 victory after Suwon were awarded four penalties, but only managed to convert one.
Masato Kudo scored twice for Kashiwa on that occasion and Yoshida will be hoping that he can find his form once more on Tuesday.
Persepolis v Al-Hilal
After finishing as runners-up in Group A, Persepolis begin the knockout stages with a home clash with Group C winners Al-Hilal of Saudi Arabia.
Persepolis head into the match having secured a morale-boosting 1-0 victory over local rivals Esteghlal on Friday, in what was the last match in a disappointing league campaign which saw the Tehran outfit finish eighth.
Branko Ivankovic could be without defenders Michael Umana and Mohsen Bengar for the fixture after pair suffered injuries in the win over Esteghlal. Midfielder Gabriel (injury) and defender Mohammad Reza Khanzadeh (suspension) are definite non-starters.
Like Persepolis, Al Hilal have not enjoyed the best of domestic campaigns, finishing third in the recently-concluded Saudi league. However, they did end on a high, beating Hajer 5-1 on Saturday.
Al-Hilal are still without the suspended Nassir Al Shamrani, while midfielder Thiago Neves is in race against time to recover from injury.
Al-Sadd v Lekhwiya
The last 16 draw produced an all-Qatar clash, with Lhoussanine Ammouta's Al-Sadd outfit facing off against Michael Laudrup's Lekhwiya who were last week confirmed as the Super League champions.
The two teams faced off as recently as Friday in the semi-final of the Emir’s Cup, with Al-Sadd claiming a 2-0 victory that is sure to give them confidence heading into Tuesday's encounter.
Al-Sadd, the 2011 AFC Champions League winners, will be without the services of defender Ibrahim Majed who has undergone foot surgery, and the suspended Jasser Yehia. However, Khalfan Ibrahim may return after being sidelined by a hip injury.
Friday's defeat ended an eight-match winning run for Lekhwiya, and despite the slip up, Laudrup has spoken of the confidence that he has in his players to claim victory on Tuesday.
The Red Knights will be boosted by the return of Mohammed Tresor for the clash at the Jassim Bin Hamad Stadium, with the defender having completed a suspension.