Southampton take on Swansea City in their opening Premier League game on Saturday with the Saints and Swans without key players in Virgil van Dijk and Gylfi Sigurdsson respectively.
Central defender Van Dijk is a reported target of Liverpool although misses the game with a virus. Sigurdsson will not be involved as it appears a move to Everton could be close to being secured.
The encounter will also mark the debut of Southampton's new coach, Mauricio Pellegrino, after he joined from La Liga side Alaves, whom he guided to a top 10 finish and the final of the Copa del Rey (where they lost 3-1 to Barcelona) in 2016/17.
Did you miss #SaintsFC boss Mauricio Pellegrino's first pre-match press conference?
Catch up on the key points with Mauricio in a Minute: pic.twitter.com/5bRdH6sWPd
— Southampton FC (@SouthamptonFC) August 11, 2017
Meanwhile, City boss Paul Clement will no doubt want to build on last season's escape from relegation by trying to get a good result at St Mary's Stadium in Hampshire.
However, talk ahead of the clash has been dominated by the futures of Van Dijk and Sigurdsson with Pellegrino saying: "Hopefully he can change his point of view, because we need the player. Virgil is an important player and we need him."
On the other hand, Clement said that any money recouped on Sigurdsson had to be spent wisely, "We have to make sure that if a player of his ability leaves, we have to get one or two very good players."
In team news, Saints have no injury concerns aside from Van Dijk with illness. The visitors will be without Ki Sung-yueng, Nathan Dyer and Fernando Llorente with injury.