Group F leaders Urawa Red Diamonds travel to Seoul on Wednesday looking for the three points that will seal their place at the top of the AFC Champions League group.
Shanghai SIPG, who level on points with Urawa on 12 points travel to Australia to face Western Sydney Wanderers.
Top the group and Urawa will play Jeju United over two legs in the round of 16 while the runners up will meet Chinese side Jiangsu FC.
The Red Diamonds have been in fine form throughout the campaign, winning four games while scoring a hatful of goals (18) in the process
The Reds beat FC Seoul 5-2 in their previous meeting, netting five first-half goals and will be confident of getting the win they need at the Seoul World Cup Stadium.
FC Seoul have nothing but pride to play for and will want some revenge for the thrashing in the earlier game between the two sides.
— 浦和レッズオフィシャル (@REDSOFFICIAL) May 9, 2017
They welcome back Spanish defender Osmar Barba from suspension.
Both teams go into the tie in poor form domestically, Urawa losing two games since thrashing Western Sydney Wanderers 6-1 on Matchday 5, while Seoul are on a run of three straight defeats.