Luis Enrique expects a difficult match against Malaga but insists victory can be the only outcome.
The Blaugranes are second in La Liga, two points behind leaders Real Madrid, having played a game more.
With Real set for an intriguing encounter against third-place Atletico Madrid, also on Saturday, Barcelona cannot afford to slip up, while hoping that Zinedine Zidane's side does drop points.
Ahead of the tie, he told reporters: "The league title passes through Malaga. If we don’t pick up three points and our rivals do then it will be much tougher for us so we are not looking beyond that.
“We have always had problems against them [Malaga], on an individual level they have a lot of talent and it will be a good test for us it we are to continue in the battle for the league.”
The last time these two sides faced each other, at Camp Nou earlier in the season, Malaga engineered a draw.
Enrique continued: "Oddly, they have done so with different coaches, Javi Gracia, Juande Ramos and now they have Michel in charge. I think it is to do with the individual talent they have, the can cause us problems in attack and defence and we have to put in a good performance to overcome that.
"We have to focus on the league first. We know we are back in Champions League actions soon and that is exciting but we are award of the risks of not being centred on La Liga."