The Royal Dutch Football Association (KNVB) confirmed on Sunday that Danny Blind has been axed as head coach of the Netherlands.
A 2-0 loss to Bulgaria on Saturday was the final nail in Blind's coffin as the Dutch find themselves fourth in Group A of the 2018 World Cup qualifiers, six points behind leaders France and three shy of play-off incumbents Sweden.
The 55-year-old Blind took charge of the Oranje midway through their ill-fated qualification bid for Euro 2016, replacing Guus Hiddink.
KNVB director Jean Paul Decossaux said in a statement: "We have respect for what Danny did for us and for the team during his tenure.
"But because the sporting results are unfortunately disappointing, and because qualifying for the World Cup in Russia is now in difficulty, we unfortunately feel forced to relieve him."
Blind added: "We were on a good roll. I think the game against Bulgaria was decisive.
"I gave everything I had. It's too bad that it stops with this now."
Under-21 boss Fred Grim will take interim charge of the side for their friendly international against Italy at the Amsterdam Arena on Tuesday.