Anything less than a win against Feyenoord at Old Trafford on Thursday night could leave Manchester United struggling to progress from Group A in the Europa League.
The Premier League side will be out to exact revenge for a 1-0 defeat in the reverse game in the Netherlands where Tonny Vilhena netted a 79th minute winner.
After four rounds played, Fenerbahce and Feyenoord both have seven points, United six, and FC Zorya Luhansk two.
Victory for Jose Mourinho's side would put them back in the top two ahead of their final group match, away to FK Zorya Luhansk.
Mourinho has already promised a rare start for summer signing Henrikh Mkhitaryan, while club captain Wayne Rooney may also be restored to the starting XI.
— Manchester United (@ManUtd) November 23, 2016
"I told him [Mkhitaryan] 'this was not the game for you' because I don’t think he needs 10 or 20 minutes from the bench.
"I said 'I think you need a good game and you need to either start or, if not, to come for the second half'. He needs less pressure and better conditions for him to express his qualities," said the Portuguese coach.
The Red Devils boss may, however, not make too many changes to his side, as with United's domestic title challenge diminishing by the week, the Europa League could provide an opportunity for a trophy and some respite for Mourinho.
He will, however, be without the injured Eric Bailly, Chris Smalling and Marouane Fellaini, while Luke Shaw is doubtful.
The Rotterdam side must make do without the suspended Eric Botteghin and injured pair Kenneth Vermeer and Sven van Beek.
Both teams have won only two of their last six games in all competitions, the Old Trafford club losing three while Feyenoord have lost one and drawn three in that period.