Roma are in danger of slipping out of second place in the Serie A standings after a late penalty condemned them to a disappointing 2-1 defeat to Atalanta on Sunday afternoon.
Despite looking second best throughout the encounter, Roma found themselves 1-0 up at half time courtesy of a Diego Perotti penalty.
However, Atalanta's dominance eventually paid off in the second period and they drew level through Mattia Caldara before 19-year-old Franck Kessie calmly slotted a penalty in the 90th minute to hand them an unexpected win.
Elsewhere, braces for Federico Bernardeschi (27', 61') and Josip Ilicic (47', 67') helped get Fiorentina get their season back on track with an impressive 4-0 win over Empoli at Stadio Carlo Castellani.
Three goals in the final 10 minutes secured a remarkable turnaround for Sampdoria as they beat Sassuolo 3-2 at Stadio Luigi Ferraris.
After a goalless, and rather boring, first half the match kicked into another gear after the break. Goals from Federico Ricci (64') and Antonino Ragusa (74') gave the visitors a commanding 2-0 lead.
But, just when it seemed like they would pull off an impressive win, Fabio Quagliarella pulled one back in the 84th minute before Luis Muriel levelled matters less than 120 seconds later.
The miraculous comeback was completed in the first minute of stoppage time when Muriel added his second of the game from the penalty spot.
A brace from Andrea Belotti helped Torino to a 2-0 win over Crotone, while Bologna recovered from an early setback to beat Palermo 3-1.
They were stunned in the ninth minute by Ilija Nestorovski's strike but fought back well and were soon level through Mattia Destro in the 20th minute.
From then on, it was all Bologna, with Blerim Dzemaili (67') and Federico Viviani (72') both getting on the scoresheet to secure a good win.
And finally, Lazio emerged from a bruising encounter with Genoa with a hard-fought 3-1 win at Stadio Olimpico.
They had the lead through Felipe Anderson's 11th minute strike, but were pegged back shortly after half time when Lucas Ocampos scored in the 52nd minute.
However, they took the lead seven minutes later through a Lucas Biglia penalty and Wallace secure the points with a fine goal in the 66th minute. Genoa's day went from back to worse when Lucas Orban when sent off in the 90th minute for a poor challenge.