Fabio Quagliarella scored the only goal of the game as Sampdoria returned to winning ways by beating Internazionale 1-0 at the Stadio Luigi Ferraris on Sunday.
An action-packed first half saw both teams strike the frame of the goal before La Samp broke the deadlock just before the break.
The hosts made the better start and created a couple of chances before the quarter-hour mark, although neither Quagliarella nor Luis Muriel tested the keeper with their respective efforts from inside the area.
Christian Puggioni was soon called into action at the other end to deny Antonio Candreva from range in the 16th minute, before Quagliarella forced Samir Handanovic into a save moments later after latching onto Muriel's through-ball.
Edgar Barreto was a whisker away from opening the scoring for the Genoans on the half-hour mark when his shot from inside the area on the right hit the near post following a corner.
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Back came Inter as Candreva drew another save out of Puggioni with an effort from outside the box in the 35th minute, before Marcelo Brozovic was denied by the woodwork for the visitors four minutes later as his shot came back off the crossbar.
The Nerazzurri looked to finish the half strongly as Mauro Icardi and Brozovic both went close to the opener, but instead it was La Samp who drew first blood just before half-time.
Karol Linetty picked out Quagliarella inside the area and the forward produced a good finish to slot home into the bottom right corner of the goal.
It was all Inter after the break as they went in search of the equaliser, with Eder missing the target from inside the area on the left in the opening minute of the second half.
Icardi failed to test the keeper with two efforts from close range just after the hour mark, while Eder couldn't direct the ball on target from Ever Banega's 71st-minute free-kick.
Ante Budimir had a late opportunity to seal the win for the home team but he was unable to beat Handanovic four minutes from time, although there was still time for Frank de Boer's side to draw level as Rodrigo Palacio drew a fine save out of Puggioni from close range before the Argentine striker hit the bar from six yards out in stoppage time.