Atletico Madrid suffered their first La Liga defeat of the season after they went down 1-0 to Sevilla at the Ramon Sanchez-Pizjuan on Sunday.
Steven N'Zonzi's 73rd-minute winner settled the match in Andalusia, although Atletico saw their hopes of a fightback dashed with the dismissal of Koke on 77 minutes.
The hosts were good value for their narrow victory, which took the club to the top of the league standings, one point clear of Barcelona and two ahead of Diego Simeone's side in third place.
Visiting keeper Jan Oblak was called into action for the first time on the quarter-hour mark as he kept out Nzonzi's close-range header from Samir Nasri's cross.
Sergio Rico was then tested moments later by Kevin Gameiro from inside the area on the left following a clever pass from Antoine Griezmann to find the striker.
After a few chances were wasted at both ends, Angel Correa should have opened the scoring for the visitors when he was released through on goal by Gameiro's flick from Diego Godin's long ball, but the Argentine sliced his shot wide from inside the box on 39 minutes.
The woodwork would come to Atleti's rescue four minutes after the restart when Nasri saw his effort from inside the area strike the left post after he linked up well with Franco Vazquez and Luciano Vietto.
Oblak pulled off a superb reaction save to deny Vitolo on the half-volley just three minutes later as Jorge Sampaoli's men went in search of the opener.
Rico had to be alert to turn way Filipe Luis' strike from the edge of the 18-yard area on 67 minutes, before the deadlock was finally broken at the other end five minutes later when Nzonzi latched onto Vietto's clipped pass to beat Oblak with a low finish from inside the box.
The visitors suffered a further setback just three minutes later with the sending-off of Koke, who picked up his second booking of the game for a foul on Adil Rami.
Vazquez had a chance to extend the hosts' lead with six minutes remaining, but failed to hit the target from range, while Godin was denied a late equaliser as Rico saved his close-range header from Griezmann's headed pass.
Earlier in the day, meanwhile, Celta Vigo returned to winning ways as a brace from Iago Aspas helped them to a 4-1 win over Deportivo La Coruna at Balaidos.
The two teams went into the break at level pegging after Raul Albentosa (37') cancelled out Hugo Mallo's opener for the hosts just five minutes prior.
But Aspas restored Celta's lead from the penalty spot in the hour mark and Fabian Orellana gave them a two-goal cushion on 78 minutes before the Spaniard struck again seven minutes from time.