Manchester City are still undefeated in the Premier League, but Swansea City are looking to surprise them in their League Cup clash at the on Wednesday.
The league leaders travel to the Liberty Stadium on the back of five straight league wins, the most recent of which was a 4-0 drubbing of Bournemouth.
The Swans, meanwhile, have now gone their last four matches without a win, including three defeats, and will be hoping that a change in competition will bring about a change in their fortunes.
Elsewhere, Manchester United will be firm favourites when they take on Northampton Town at Sixfields Stadium.
The Red Devils are under pressure after losing their last three on the trot, with league defeats to Watford and neighbours City sandwiching their Europa League loss to Feyenoord.
Having won their first three league matches, manager Jose Mourinho will view this as a good chance to return to winning ways against third-tier opposition.
The Cobblers recently tasted defeat in League One away to Chesterfield, after having won their previous two league matches, but will need something special to surprise an under-pressure United side.
Southampton and Crystal Palace are both looking to get over a poor start to the league when they meet at St Mary's.
The Saints finally got their first win of the campaign after starting with two draws and two defeats, beating Swansea 1-0 at home after enjoying Europa League victory over Sparta Prague.
The Eagles also started slowly with two defeats followed by a draw, but they have now beaten Middlesbrough and Stoke City in recent weeks, along with victory over Blackpool in the previous round of this competition, and they will want to keep that momentum going.
It's been a tough couple of weeks for both Queens Park Rangers and Sunderland, putting them both in need of a positive result in their match at Loftus Road Stadium.
QPR have suffered back-to-back defeats in the Championship against Newcastle United and Huddersfield Town, the former being a 6-0 drubbing that showed their defensive insufficiencies.
The Black Cats have also tasted defeat in their last two games against Everton and Spurs, being unable to score in either of them. That leaves them with just a single point from their opening five fixtures, and already needing to turn their season around.
West Ham have been leaking goals of late, and are in desperate need of some good fortune when they take on Accrington Stanley at the London Stadium.
The Hammers have now lost their last four in a row, starting with Europa League defeat to Astra before losing to Manchester City, Watford, and West Brom in the Premier League. Having let in 11 goals in just those last three matches, something needs to change.
Stanley, three tiers down in League Two, have managed back-to-back victories over Notts County and Portsmouth in recent weeks, but the 11th-placed Lancashire side will be out of their depth against the Irons.
Stoke City have been in disastrous league form of late, and will be hoping to take their mind off it when they take on Hull City at the Bet365 Stadium.
The Potters are rock-bottom of the Premier League after losing their last four on the trot, and have just one point to their name so far. Their only refuge has been in the League Cup, where a 4-0 whipping of Stevenage gave them some relief from their top-flight gloom.
The Tigers have also hit a rough patch lately after having won their first two league games. However, they played well in defeats to Manchester United and Arsenal either side of a draw with Burnley, although their recent record against Stoke is not very good.
Tottenham Hotspur seem on course to destroy Gillingham when they welcome the League One side to White Hart Lane.
After impressing last season, Spurs are looking capable again this campaign. Points dropped against Merseyside duo Liverpool and Everton have been recovered with three league wins to keep them third in the Premier League standings.
The Gills, meanwhile, have taken just one point from their last three matches in England's third tier, where they sit an unimpressive 13th, and will need a special performance to stand up to the Lilywhites.
Wednesday's League Cup fixtures:
- Queens Park Rangers v Sunderland
- West Ham United v Accrington Stanley
- Southampton v Crystal Palace
- Swansea City v Manchester City
- Fulham v Bristol City
- Northampton Town v Manchester United
- Tottenham Hotspur v Gillingham
- Stoke City v Hull City