Sunderland forward Jermain Defoe will miss Wednesday's EFL Cup clash with Queens Park Rangers, after sustaining an injury against Tottenham Hotspur at the weekend.
David Moyes' men have endured a torrid start to the 2016/17 league campaign, picking up just one point from their opening five fixtures.
In fact, their last victory came in the league cup in August, when they condemned Shrewsbury Town to a 1-0 defeat courtesy of a 83rd-minute strike by Adnan Januzaj.
Defoe, who is the club's top goalscorer with two goals in five games, will most likely be available for selection when the Black Cats face Crystal Palace on Saturday, 24 September.
"Jermain took a bit of an injury in the game – he's got a knock – so he won't go and more importantly I need to make sure he's fit for the game at the weekend," Moyes told the club's official website.
The former Manchester United mentor also revealed the unavailability of newly-signed forward Victor Anichebe.
"Victor isn't ready to play yet but he's stepped up his training and he's getting much closer to match fitness," Moyes added.
"There will be some young boys involved but we've already had players such as Duncan Watmore, Lynden Gooch and Jordan Pickford play well.
"We have a young team so the addition of players like Lee Cattermole, Jan Kirchhoff and Steven Pienaar has given us more experience, but we've had a young side for most of the season and it will be the same tomorrow evening."