Manchester United manager Jose Mourinho has confirmed that club captain Wayne Rooney will not travel with the squad for their Europa League tie against Dutch side Feyenoord on Thursday.
Rooney has started in all four of United's Premier League games this season and played a full game for England in a World Cup qualifier a week ago.
Full-backs Antonio Valencia and Luke Shaw as well as Jesse Lingard have also not been included in the 20-man travelling squad while Henrikh Mkhitaryan and Phil Jones miss out through injury.
The latter was substituted at half-time of Saturday’s derby defeat to Manchester City along with Lingard.
On Rooney, Mourinho told reporters: "He has played every game since the start of the season and he played 90 minutes with England.
"I want him to be fresh for the next games. He plays in an attacking position, where I have lots of options. He took it professionally, like the other players."
Striker Zlatan Ibrahimovic is in the squad while Marcus Rashford is expected to start at the De Kuip Stadium in Rotterdam.
The Red Devils are in Group A of the Europa League alongside Feyenood, Turkish side Fenerbahce and Zorya Luhansk from Ukraine.
Squad: De Gea, Romero, Johnstone, Darmian, Bailly, Blind, Fosu-Mensah, Rojo, Smalling, Carrick, Fellaini, Herrera, Mata, Memphis, Pogba, Schneiderlin, Young, Ibrahimovic, Martial, Rashford.