Valencia were forced to come from a goal down to beat third division outfit Barakaldo 3-1 in the first leg of their Copa del Rey last 32 clash.
On the day that Gary Neville was confirmed as the club's manager for the reminder of the season, Neville's brother, Phil, and caretaker boss Voro oversaw a victory away from home.
It looked like it could be another long night for Valencia when Alain Arroyo opened the scoring for the home side in the 16th minute, but Valencia responded just three minutes later, with Joao Cancelo grabbing the equaliser.
Jose Gaya put Valencia ahead in the 65th minute before Dani Parejo put the result beyond doubt in injury time when he found the back of the net from the penalty spot after Jaume Valens brought down Enzo Perez.
In an all-La Liga clash, Alvaro Vadillo and Juan Vargas got on the scoresheet as Real Betis beat Sporting Gijón 2-0. After a goalless first half at the Estadio Benito Villamarín, Vadillo opened the scoring a minute after the interval, with Vargas making the result safe in added time.
Rayo Vallecano too were able to get the first leg advantage over top flight rivals Getafe. Lass Bangoura put Vallecano ahead in just the sixth minute, before Patrick Ebert doubled his side's lead in the 28th minute.
It was smooth sailing for Sevilla as they downed UD Logrones 3-0 on their travels. Coke opened the scoring in the 12th minute before Michael Krohn-Dehli doubled Sevilla's advantage with a smart finish in the 38th minute.
Ciro Immobile's 57th-minute effort ensured that Sevilla head back to the Estadio Ramón Sánchez Pizjuán for the second leg with a commanding advantage.
Iago Aspas grabbed a brace as Celta Vigo beat Almeria 3-1. Aspas opened the scoring in the 16th minute before notching up a second in the 35th minute. Just as it appeared that Celta were running away with the match, Jose Pozo found the back of the net in the 44th minute to put Almeria back in the contest.
There would be no first leg comeback for the hosts, with John Guidetti making it 3-1 in the 72nd minute.
A 10-man Deportivo La Coruna side needed to come from a goal down to secure a 2-1 victory over Llagostera of the Segunda División.
Juanjo Expósito put the home side ahead in the first half before Fedrico Cartabia drew Deportivo level. Victor Sanchez's side were then reduced to 10 men when Luisinho was shown a second yellow in the 65th minute. Despite Llagostera's numerical advantage, it was Deportivo who secured the winner, with Oriol Riera finding the back of the net in the 74th minute.
Almeria 1-3 Celta Vigo
Barakaldo 1-3 Valencia
Real Betis 2-0 Sporting Gijon
Llagostera 1-2 Deportivo La Coruna
UD Logrones 0-3 Sevilla
Rayo Vallecano 2-0 Getafe