West Ham have vowed to serve life-long bans to those fans responsible for attacking the Manchester United team bus ahead of Tuesday's historic match.
The coach was caught up in a throng of Hammers supporters outside Upton Park as they prepared for the last-ever game at the ground, with the club moving to the Olympic Stadium next season.
Projectiles thrown by the crowd damaged the bus as it passed through the masses, and Metropolitan Police confirmed an officer and a bystander had sustained minor injuries in the incident.
The east Londoners intend to take stringent action against the vandals once they have been identified, while the Football Association plan to launch their own probe into the unsavoury matter.
A statement from the Hammers read: "It was an extraordinary night full of extraordinary moments in front of extraordinary fans, 99 percent of whom behaved impeccably and were a credit to the club.
"We have already had thousands of tweets and emails from fans to say how proud they were to be a part of such a special evening in West Ham's history.
"However, we are aware that there were some supporters outside the Boleyn Ground who didn't act in an appropriate way when the Manchester United team bus was damaged.
"That was not acceptable and we will work with the police to identify those responsible and ban them for life."
The police added in a statement: "We are aware that a number of items were thrown towards Manchester United's coach this evening, Tuesday, 10 May.
"One police officer and a member of the public sustained minor injuries. 'There have been no arrests. An appropriate policing plan is in place."