Sunderland host Everton at the Stadium of Light on Wednesday evening knowing a win will see them retain their top-flight status.
Jermain Defoe's 15 league goals this season has given the Wearsiders a glorious chance of survival and the former England international will be a key figure to look out for.
Victory against the 12th-placed Toffees will relegate fierce local rivals Newcastle as well as Norwich before the final game of the season.
Black Cats centre-back Lamine Kone is fit to face the Merseyside outfit despite limping off against Chelsea at the weekend with a thigh injury, while defender Billy Jones is the only absentee for the crucial fixture.
Everton defender Ramiro Funes Mori is available for selection for manager Roberto Martinez after his three-match suspension, while Gareth Barry and Seamus Coleman could return from respective groin and hamstring injuries.
Sam Allardyce, whose side has picked up eight points from their last five games, is hopeful his squad can put in a repeat performance of their 3-2 victory over Chelsea on Saturday.
"Our destiny is in our own hands. Now we must take full advantage of that position and try to finish it off on Wednesday," he said.
"We need a repeat of the performance and support we had against Chelsea, particularly in the second half. Don't come to the Stadium of Light with the expectation that it's job done because it isn't."
Martinez's job is reportedly on the line and he knows a negative result against the Premiership strugglers could be the end of his tenure at Goodison Park as their slim chances of a top-half finish will diminish.
"There is a lot riding on the game for us after the performance we had (at Leicester). We need to react and we need to perform in the highest possible level," the Spaniard said.
"It is good that we have a game around the corner but the importance of our performance is as big as you could feel we had in any other day in the season."