Dortmund will be looking to bounce back from Europa League disappointment when they host Hamburger SV at Signal-Iduna Park on Sunday.
BVB were beaten by Liverpool and former manager Jürgen Klopp in their Europa League quarter-final on Thursday, with the German side racing into a two-goal lead in the first 10 minutes before losing the tie in stoppage time.
With European glory now out of reach, Thomas Tuchel's men can focus purely on the Bundesliga, where they are currently second in the standings, seven points behind league leaders Bayern after drawing 2-2 with Schalke in their most recent league match.
Hamburg, meanwhile, are 10th in the standings having won three and lost three of their last six league games, but they did manage a 3-1 win over Dortmund earlier in the campaign, and Die Rothosen will be looking to do the double over the title chasers.
Speaking after their defeat at Anfield, Tuchel admitted that his team are deflated at being knocked out of the tournament, but what is now important for them is how they react to the disappointment, and how quickly they can rediscover their swagger.
"It feels very sobering. Now we feel very, very empty," he said. "Our power density and our standards are too high to simply brush aside this defeat.
"The interesting thing will be to see how we deal with it as a unit, how much energy it costs us and whether we manage to put the disappointment behind us by next Wednesday in Berlin at the very latest.
"That's also a characteristic of sport. There are no matches without defeats and losers. These are lessons that are part of it."
The match at Signal-Iduna Park is being eagerly anticipated by Hamburg attacking midfielder Michael Gregoritsch, who is looking forward to visiting Dortmund's historic ground looking for a result against one of Europe's finest teams.
"I have always wanted to play there at some time," the Austrian told his club's official website. "I get the chance to do so on Sunday and can't wait.
"I hope we keep things as tight as we did in our first meeting and that we take our chances better. That way we have a realistic chance of taking something from the game even against such a quality side."
Fans from both teams will be keeping their eyes trained on Dortmund's lightning-quick forward Pierre-Emerick Aubameyang, who has already banged in 23 goal in his 27 Bundesliga appearances, including a late consolation in their loss to this opposition earlier in the season.
Hamburg midfielders Lewis Holtby and Nicolai Müller could also be worth watching for the visitors, as both of them played under Dortmund boss Tuchel at former club Mainz.
In team news, Dortmund will have to make do without defender Neven Subotic (arm), while Josip Drmic (knee) will miss out for Hamburg, while Ivica Olic and Ashton Götz are also unlikely to feature.