FC Twente eased to a 2-0 win over Groningen on Saturday thanks to goals from Zakaria el Azzouzi and Jerson Cabral.
Elsewhere, ten-man PEC Zwolle lost 1-0 to Cambuur at the Cambuurstadion, Jack Byrne scoring after Ouasim Bouy was sent off for two bookable offenses.
Over at Philips Stadion, PSV Eindhoven maintained their slender lead at the top of the standings following a 2-0 win over ADO Den Haag.
It took until the 72nd minute for PSV to find the breakthrough, with Marco van Ginkel firing home, before Luuk de Jong doubled the lead in the 82nd minute.
Terell Ondaan scored a vital goal as Willem II secured what could prove to be a crucial 1-0 win over Vitesse in their bid for Eredivisie survival this season.
FC Twente 2-0 Groningen
Cambuur 1-0 PEC Zwolle
PSV Eindhoven 2-0 ADO Den Haag
Vitesse 0-1 Willem II