Jurgen Klopp will be searching for his first win as Liverpool manager when Southampton make the long journey to Anfield on Sunday.
Klopp's first assignment after taking over the reins from former boss Brendan Rodgers was a trip to Tottenham last weekend, where his side earned a point in a goalless draw.
The German will face a stern test from Ronald Koeman's team, who are unbeaten in their last three league outings and have lost just two of their opening nine matches.
The ninth-placed Saints are tied on 13 points with the Reds, who are two spots further back in 10th and eager to give Klopp his first taste of victory at the helm.
The Merseysiders have an identical record to the visitors from the south coast, but an inferior goal difference as they have struggled to find the back of the net this term.
Klopp must make his preparations for the clash without striker Daniel Sturridge, who is set for another scan on his knee injury and further treatment possibly.
However, Christian Benteke could alleviate Sturridge's absence as the Belgian striker is in contention to return to the starting XI after he made his comeback as a substitute in the Europa League tie against Rubin Kazan.
Roberto Firmino is also pushing for a start after the Brazilian also came off the bench against the Russian club on Thursday for his first appearance since being sidelined by injury last month.
Visiting boss Koeman could restore Maarten Stekelenburg to the starting line-up this weekend after the Dutch goalkeeper sat out the 2-2 draw against Leicester with a back complaint.
Portuguese defender Cedric is also in the frame, having recovered from a knock to the eye in the clash with the Foxes last weekend, although striker Jay Rodriguez is rated doubtful.