An unbeaten 95 from opener Kraigg Brathwaite put the West Indies in a position to establish a first innings lead over Pakistan for the first time in the series on day two in Sharjah.
The opener showed great patience in anchoring the innings from the outset facing 206 balls in the heat of the UAE against a quality attack.
The West Indies had earlier wrapped up the Pakistan innings, with the hosts adding 23 runs to their overnight total to finish on 281 all out.
Alzarri Joseph picked up both the wickets to fall for Pakistan to finish with figures of 2 for 57 while Devendra Bishoo was the pick of the bowlers with a return of 4 for 77 while Shannon Gabriel took 3 for 67.
The West Indies stuttered to lunch losing Leon Johnson (1), Darren Bravo (11) and Marlon Samuels for his tenth Test duck since 2011, the most by any top order batsman during that period.
The Windies took lunch at 38 for 3, with Brathwaite being joined by the promising Jermaine Blackwood.
Blackwood (23) would depart in the seventh over after lunch but his wicket would be the only one to fall in the session as the West Indies fought back.
Brathwaite and Roston Chase would come together and take the West Indies to tea on 141 for 4.
Chase (50) fell in the evening session shortly after reaching his half century when a lapse in concentration saw him flash at a wide delivery from Mohammad Amir who beat the allrounder for pace.
Wicketkeeper Shane Dowrich helped put on a stand of 83 with Brathwaite whacking five fours and a six on his way to 47.
Pakistan pegged the Windies back with a late wicket as Wahab Riaz had Dowrich chop the ball onto his stumps for a soft dismissal but the men from the Caribbean will be very happy to reach the close on 244 for 6 just 37 runs behind Pakistan.
So far Amir has been the pick of the Pakistan bowlers taking 2 for 44 on day two.