Tabraiz Shamsi is the only uncapped player selected in South Africa's 15-man squad for the ODI triangular series against the West Indies and Australia taking place in the Caribbean in June.
The Unlimited Titans 26-year-old left-arm wrist spinner will become the 116th player to represent the Proteas in the 50 overs format if he gains selection into the starting XI, and together with Imran Tahir will be the wrist spinners on tour.
CSA selection committee convener, Linda Zondi, said: "We have opted for three specialist spinners as we anticipate the pitches in the Caribbean to be on the slow side.
"Tabraiz has certainly earned his call-up following outstanding form both in our domestic cricket and in some of the major domestic T20 leagues including the Caribbean Premier League."
"He has shown what he can do in the T20 leagues against international batsmen. I am quite excited about the state of our spin bowling and the variety we have.
"We are sending two wrist spinners to the Caribbean plus left-arm and right-arm finger spin options.
"Spin bowling is becoming an increasingly important part of both limited overs formats and we are only just over a year away from the ICC Champions Trophy Tournament in England."
Wayne Parnell returns to the Proteas ODI squad for the first time since last year's ICC World Cup in Australasia while fast bowler Dale Steyn has been rested.
Zondi explained: "In the short term our immediate focus must be to get back among the top ranked Test nations and for this reason we are resting Dale Steyn for this tour.
"He is vital to our ambitions in the longest format and he is going to have a heavy workload in the months ahead with home and away series against New Zealand, a home series against Sri Lanka and an away Test series in Australia which is where we need to perform.
"He is certainly not out of the ODI picture and could well feature in the home series against Australia later this year.
Wayne has the ability to become a quality all-rounder for us and, like Tabraiz, he is being rewarded for outstanding domestic form."
Batsman Faf du Plessis has been included in the squad despite the current injury to his finger, and is expected to return to action for the Proteas' second match of the triangular series.
Proteas ODI squad: AB de Villiers (capt), Kyle Abbott, Hashim Amla, Farhaan Behardien, Quinton de Kock, JP Duminy, Faf du Plessis, Imran Tahir, Morne Morkel, Chris Morris, Wayne Parnell, Aaron Phangiso, Kagiso Rabada, Rilee Rossouw, Tabraiz Shamsi.