What makes this fight interesting is that it is a unification bout after Werdum claimed the interim belt last year when Velasquez was out of action injured.
In the other big fight on the cards, two former lightweight champions Eddie Alvarez and title holder Gilbert Melendez will be up against each other.
TUF winner Kelvin Gastelum, who lost recently for the first time, will be hoping to get back to winning ways when he faces veteran UFC competitor Nate Marquardt, who has lost four of his last five fights.
Latin America winner Yair Rodriguez will be up against Charles Rosa, and rounding off the main card will be a female strawweight fight between Tecia Torres and Angela Hill.
Cain Velasquez vs. Fabricio Werdum
Eddie Alvarez vs. Gilbert Melendez
Kelvin Gastelum vs. Nate Marquardt
Yair Rodriguez vs. Charles Rosa
Angela Hill vs. Tecia Torres
Chico Camus vs. Henry Cejudo
Drew Dober vs. Efrain Escudero
Alejandro Perez vs. Patrick Williams
Johnny Case vs. Frank Trevino
Augusto Montano vs. Cathal Pendred
Gabriel Benitez vs. Clay Collard
Andrew Todhunter vs. Albert Tumenov