Marquez, who has fought both boxers, believes Pacquiao will be disadvantaged if the fight goes to a decision, and advises that the Filipino goes for a knockout.
The Mexican boxer fought Pacquiao four times in total, he lost the first three on a decsion and won the fourth when he managed a KO. He was quoted by theboxingvoice.com saying that Las Vegas judges are likely to favour the American.
He said: "He needs to go for the knockout. In Vegas, the judges are going to favor Mayweather if a fight goes to a decision. "
Marquez also told boxingscene both boxers are definitely feeling the effects of age, and previous fights. He hopes his own KO victory over the Filipino has not affected him too much.
He said: "After that big knockout in 2012, a fighter's mind can change. A big punch to the jaw, and he can relive those moments of 2012. Hopefully, this does not happen and it becomes a great fight for the fans who have waited, but in the end, Floyd Mayweather and Manny Pacquiao are not at their best.
"I’m not saying they are not [great fighters]. Floyd Mayweather is considered the best pound for pound, followed by Manny Pacquiao, but what I am saying is they are not at their best – athletically speaking – because that fight should have happened three years ago – but it remains as an interesting fight that all of the fans want to see.
"It is a very dangerous fight [for Mayweather], because he has not faced any opponent with the speed or aggression of Pacquiao, and in this case also with power. Mayweather has not faced an opponent with these characteristics."