Wilder won the title in January, winning a comfortable 12 round decision over Bermane Stiverne.
The 29-year old Wilder has won 32 of his 33 fights via knockouts and is up against Molina who has lost twice in 23 fights but has 17 knockouts behind his name.
According to Wilder the reason they chose Molina for his first defence was because he understood what a big opportunity he was being offered by getting a title shot.
"We have a lot of other opponents, but Molina was the one to understand the opportunity that lies at hand," said Wilder.
"Some people can price themselves out and some teams make it so difficult that the fight won't happen. They can really block themselves out from getting the fight. You can have the money or the opportunity.
"Molina understands what the situation is, and he stepped up to the plate and understands the opportunity at hand to be the world heavyweight champion," he added.
Wilder believes that by going the full 12 rounds in his last fight against Stiverne proved to his critics that he can go the distance and can take a punch.
"My last fight I proved to everyone what I was capable of. I can go 12 rounds and take a punch. I can be just as fresh in the 12th round as the first.
"The sky's the limit in what we're trying to do. I represent the state. Even though I'm from Tuscaloosa, it's not just where my gym is in Northport or Coffeeville. I represent the state of Alabama.
"I need a home territory and a home state not only where we can bring in local people, bring in the nation, but also bring in the whole world," he added.