Klitschko (64-3, 54 knockouts) is the holder of the WBA, IBF, WBO, IBO and The Ring heavyweight titles, his last loss was to Lamon Brewster in 2004. Since then he has won a straight 22 bouts and had 18 title defences.
In a chat with philly.com, Homes feels that Klitscho is just a big guy with power, while Wilder (34-0, 33 KOs) is also big but has a decent jab and if he learns to develop his all round skills then he could beat the champion.
"He ain't talented; he's just a big guy with some power," said Holmes, 65, who once defended the heavyweight title 20 straight times.
"I think the big guy from South Carolina [WBC champion Deontay Wilder] has the size and a decent jab. If he develops it more, I think he can beat him.
"If he uses his jab and really learns how to step side to side, he can beat him," he added.
Klitschko will face Tyson Fury (24-0, 18 KOs) on October 24 in his next bout, while Wilder does not have an opponent yet for his September 26 title defence.