Wang is bidding to become the first shuttler to win the women's singles title three times in a row since countrywoman Zhang Ning (2003-2005), while men's No. 1 Chen is aiming to win his first Singapore Open title.
China will send a powerful 23-man team even though the Super Series tournament falls just outside the qualifying window for the 2016 Rio Olympics.
Singapore Open organising chairman Ng Yoke Weng said: "It is great news for local fans that world badminton powerhouse China is sending a strong squad for the upcoming OUE Singapore Open.
"While the 2015 edition falls outside the qualification period, the 2016 instalment of the event should be one of the last few tournaments where shuttlers will fight for the remaining points.
"With that said, we are still confident that top players will come for the OUE Singapore Open. The entries that we have received prove that point."
The US$300,000 ($406,000) tournament will take place from April 7 to 12 at the Singapore Indoor Stadium.