Zwiebler saw off Kuo Ching-Hung of Chinese Taipei 21-13, 21-14 in 39 minutes to set up a clash with ninth seed Ajay Jayaram. The German is joined in the last eight by second seed Xue Song who eased past Anand Pawar 21-17, 21-16, and Chong Wei who was made to work for a 21-17, 20-22, 21-10 win over fifth seed Wong Wing Ki Vincent.
In the women's singles, there was a surprise result with second seed Beiwen Zhang going down 21-15, 21-11 to Kaori Imabeppu. Zhang had struggled in her opening match of the tournament on Wednesday, and the American could do nothing to prevent her second-round defeat in just 36 minutes.
Zhang was not the only seed to be defeated, with sixth seed Beatriz Corrales of Spain suffering defeat at the hands of Aya Ohori, while Yui Hashimoto accounted for eighth seed Sayaka Sato.
Local favourite Michelle Li kept her charge on course with a 21-14, 21-13 victory over Tanvi Lad.
In the men's doubles, top seeds Andrei Adistia and Hendra Aprida Gunawan put an end to the hopes of the Canadian duo of Phillipe Charron and Toby Ng, but they were one of the few seeds to progress in the division.
Second seeds Adam Cwalina and Przemyslaw Wacha, third seeds Michael Fuchs and Johannes Schoettler, fourth seeds Manu Attri and B. Sumeeth Reddy, and the fifth-seeded pairing of Junhui Li and Yuchen Liu all defeated.
The carnage did not end there though, with the seventh seeds Baptiste Careme and Ronan Labar, and eighth seeds Andrew Ellis and Peter Mills, also sent packing.
In the women's doubles, it was smooth sailing for top seeds Eefje Muskens and Selena Piek, and second seeds Shizuka Matsuo and Mami Naito.
In the mixed doubles there was disappointment for the home fans, with seventh seeds Toby Ng and Alex Bruce beaten 22-20, 21-17 by Yang Lee and Wu Fang Chien.