Defenseman Ryan Whitney and Ryan Malone also tallied as second-seeded Pittsburgh grabbed a commanding 3-0 advantage in the best-of-seven series.
Captain Sidney Crosby had two assists for the Penguins, who became the fourth team in league history to open the post-season with an 11-1 record.
"We're being consistent right now," Crosby said. "We have a great attitude. The reward you get for making sure that you take each game serious and that you're consistent - but I don't think we feel like we've archived anything. I think that we're just happy with the attitude and way we're working."
RJ Umberger scored for sixth-seeded Philadelphia, who will look to avoid being swept when they hosts Game Four on Thursday.
Only two teams have overcome a 3-0 deficit in NHL history - the 1942 Toronto Maple Leafs, who accomplished the feat against the Detroit Red Wings in the Finals, and the 1975 New York Islanders in the quarter-finals against Pittsburgh.