Jets coach Rex Ryan confirmed the worst possible diagnosis for the perennial Pro Bowler after he was injured in Sunday's 23-20 overtime win over Miami.
Revis suffered a non-contact knee injury and was left writhing in agony on the turf, and although Ryan holds out a slim hope of him returning, the signs point to him having season-ending surgery.
"Obviously that's a significant injury and it's something that we're going to have to overcome as a football team," Ryan said.
"For him I feel bad about it because he's such a great player and a great team-mate."
Revis picked up the injury during the third quarter of the team's win in Florida, and he will need to wait two weeks before having surgery on an injury that usually six months at the very least to recover from.
Revis had already been out with concussion but had returned for the Dolphins game, and the Jets defence could have done with keeping him in the line-up as they struggle to reach their usual level of performance.
2010 first round draft pick Kyle Wilson will now slot into Revis' position at cornerback opposite Antonio Cromartie, but Ryan is under no illusion that Revis will be a huge loss.
"It's just disappointing," Ryan added. "This guy wants to win. As great a player as he is individually, he's a great teammate and just wants to win. That's why he was so excited about this year."