After successive 13-run victories, the Reds proved too strong at the Great American Ball Park - with a three-run eighth putting paid to the visitors.
Jake Peavy impressed on his Boston Red Sox debut, giving up just four hits and two runs over seven-plus innings against the Arizona Diamondbacks to set up a 5-2 win at Fenway Park.
Wil Myers hit a walk-off single as the Tampa Bay Rays defeated the San Franciso Giants 2-1 and Dan Haren shut out the Milwaukee Brewers in seven innings with six strikeouts as the Washington Nationals won 3-0.
Francisco Liriano fired seven scoreless innings with six strikeouts while working around five walks as the Pittsburgh Pirates beat the Colorado Rockies 5-2.
The Seattle Mariners snapped a four-match losing skid with an 8-4 victory over the Baltimore Orioles, while the Oakland Athletics ended a three-game run of defeats with a 4-2 win over the Texas Rangers.
Justin Upton crossed the plate to give the Atlanta Braves a lead Craig Kimbrel preserved in the 5-4, 12-inning win over the Philadelphia Phillies, while Justin Maxwell belted a pinch-hit home run in the 12th to push the Kansas City Royals to a 4-3 win over the New York Mets.
It was a bad night for the Chicago clubs, with the Cubs losing 3-0 to the Los Angeles Dodgers and the White Sox going down 3-0 to the Detroit Tigers.
It was also 3-0 at Petco Park, where the New York Yankees sunk the San Diego Padres.
Elsewhere, the Los Angeles Angels defeated the Toronto Blue Jays 7-3, the Houston Astros downed the Minnesota Twins 6-4 and the Cleveland Indians edged the Miami Marlins 4-3.