Miguel Cabrera bagged a grand slam, as the Indians tore their opponents in the fourth scoring eight runs on what a miserable day for the O's.
Starter Jason Hammel was ejected for hitting Matt Tuiasosopo, with J.J. Hardy's two home runs the only silver lining on a dark cloud.
The Indians were 5-0 victors over the Tampa Bay Rays as Ubaldo Jimenez dominated, holding the Rays scoreless in eight innings. He allowed just four hits and registered seven strike outs, with while on offense, Jason Giambi and Asdrubal Cabrera hit home runs.
AL East leaders Boston Red Sox destroyed rivals the New York Yankees 11-1, with Mike Napoli belted his fifth career grand slam in the fifth, while Daniel Nava and Stephen Drew also scored home runs.
National League central leaders, the St Louis Cardinals dominated the San Francisco Giants, registering an 8-0 victory, with seven of their runs coming in the third innings. They were equally dominant in the second game, running out 7-1 winners.
AL West leaders Texas Rangers suffered a shock defeat against AL Central's bottom side, the Kansas City Royals.
The Atlanta Braves extended their lead at the top of the NL east to five an a half games after they beat second-placed Washington Nationals 2-1.
Dexter Fowler's single in the 10th saw the Colorado Rockies beat the Los Angeles Dodgers 7-6, while in another game which require an extra inning, Josh Reddick's RBI ensured the Oakland Athletics picked up a 4-3 win over the Chicago White Sox.
The Pittsburgh Pirates drew a blank for the second successive game against the Cincinnati Reds as they went down 2-0,
The Royals put up three runs in the 10th to clinch the win, with George Kottaras' line drive bringing home Eric Hosmer and Billy Butler.
The Miami Marlins hammered the New York Mets 8-1 to record only their second series win of the year, the Minnesota Twins beat the Seattle Mariners 5-4 and the Milwaukee Brewers recorded a 5-4 win over the Philadelphia Phillies.
The San Diego Padres won 4-3 against the Toronto Blue Jays, while the Houston Astros beat the Los Angeles Angels 2-0.