On the day the injured Russell Westbrook underwent surgery on his right knee, ruling him out of the rest of the play-offs, Durant stepped up in his absence and also pulled down 14 rebounds, while Serge Ibaka added 17 points and 11 boards to put the Thunder 3-0 up in their best-of-seven first-round series.
James Harden paced the Rockets with 30 points.
Nate Robinson scored 34 points as the Chicago Bulls rallied late in regulation and beat the Brooklyn Nets 142-134 in triple overtime to go 3-1 up in their series.
The Bulls trailed by 14 points late on in the fourth, but Robinson scored 12 straight points then assisted Carlos Boozer to tie the game.
Deron Williams had 32 points and 10 assists to lead the Nets.
Zach Randolph and Marc Gasol each scored 24 points as the Memphis Grizzlies levelled their series with the Los Angeles Clippers at 2-2 courtesy of a 104-83 win.
Gasol also grabbed 13 rebounds for the Grizzlies, while the Clippers got 19 points apiece from Chris Paul and Blake Griffin.
Al Horford had 26 points and 16 rebounds as the Atlanta Hawks eased to a 90-69 victory over the Indiana Pacers, edging ahead 2-1 in the series.