The Heat took a 114-90 scoreline as Dwayne Wade poured in 33 points and the on-fire LeBron James compiled the 35th triple-double of his career.
The Los Angeles Clippers made it 40 wins for the season as they brushed aside the Utah Jazz at the Staples Center.
The Pacific Division pace-setters took a 107-94 success and Caron Butler led with 21 points as they finalised a season sweep over the Jazz.
Central Divison leaders the Indiana Pacers also won, 90-72 over the Detroit Pistons.
Al Horford scored the decisive two-point shot with less than six seconds to play as the Atlanta Hawks squeezed past the Milwaukee Hawks 103-102.
The Denver Nuggets had six players in double figures, led by Ty Lawson's 20, as they mustered a 113-99 success over the Charlotte Bobcats.
The Cleveland Cavaliers unpacked 39 points in the fourth quarter on their way to a 118-94 victory at the Orlando Magic, Marreese Speights topping the scoring charts with just 18.
In the remaining fixture, Emeka Okafor picked up a double-double, including the decisive free-throw in the closing seconds, as the Washington Wizards edged the Houston Rockets 105-103.