Bryant poured in 21 points as well as eight rebounds as the Lakers showed no signs of missing the injured Dwight Howard and the suspended Metta World Peace.
They appear to be on a hot streak at the moment with six wins in their last seven matches.
The Indiana Pacers have also been in fine form recently and sealed their 15th consecutive home victory after seeing off the challenge of the Atlanta Hawks.
Paul George top-scored with 29 points, while David West contributed 15 points and seven rebounds as the Pacers triumphed 114-103 for their fourth victory in a row.
A stunning fourth quarter propelled the Phoenix Suns to a 96-90 success over a shellshocked Memphis.
The Grizzlies looked on course for victory with a 71-65 lead at the end of the third quarter, but the Suns were inspired by Goran Dragic, who scored 15 of his 17 points in the final period.
The Houston Rockets tied an NBA record with 23 three-pointers in their 140-109 win over Golden State, while the Denver Nuggets rallied in the final quarter to defeat the Milwaukee Bucks 112-104 for their seventh straight win.