Paul scored 24 points and provided 13 assists, while Griffin had 21 points and 13 rebounds as the Clippers took the lead midway through the first quarter and never surrendered it.
Jimmer Fredette led the Kings from the bench with 16 points.
Tony Parker scored 25 points as the San Antonio Spurs bounced back from consecutive defeats by beating the New Orleans Hornets 99-94.
The Spurs had lost four of their last five, including both their last two, but led by Parker and Tim Duncan, who had 15 points and 10 rebounds, they inflicted a 10th straight defeat on New Orleans.
Luol Deng had 29 points and 13 redounds to lead the Chicago Bulls to a 110-106 win over the Knicks on a bad-tempered evening in New York.
Carmelo Anthony, who led the Knicks also with 29 points, was one of four players to be thrown out of the game.
Monta Ellis scored 27 points as the Milwaukee Bucks pulled away from the Boston Celtics in overtime for a 99-94 win.
Ellis led the surge with five points in the additional period, while Paul Pierce scored 35 points in a losing cause for the Celtics.
Greg Monroe led a balanced Detroit offence with 15 points as they strolled past the hapless Washington Wizards 100-68.
The Pistons snapped a six-game losing streak and were never behind against the Wizards, whose league-worst record slipped to 3-21.
The Charlotte Bobcats saw their league-worst losing streak hit 14 games as Stephen Curry scored 27 points in a 115-100 win for the Golden State Warriors.
Rudy Gay poured in 26 points to lift the Memphis Grizzlies to a 92-82 win over Dallas Mavericks for a fourth straight victory.
The Indiana Pacers claimed a 99-89 win over the Cleveland Cavaliers, who fell to their sixth consecutive loss, while the Philadelphia 76ers ended a five-game losing streak by beating the Atlanta Hawks 99-80 and the Toronto Raptors made it five wins in a row by edging out the Orlando Magic 93-90.