The Eagles said Van Buren died of pneumonia at the age of 91.
He played for the Eagles from 1944 to 1951 before a knee injury ended his career. Before his arrival the Eagles had never won the NFL title.
Van Buren was named on the NFL's 75th anniversary team in 1994.
Eagles chairman Jeffrey Lurie said on the team's website: "On the field and off, as a player, a leader and a man, Steve Van Buren embodied the finest characteristics of our city and our sport. He was a friend and an inspiration to generations of fans, and the model of what an Eagle should be."