Jamal Crawford scored 36 points and Matt Barnes 24, each one off their season-high totals, in a strong team effort in which all five Clippers starters reached double figures.
Blake Griffin had 20 points and DeAndre Jordan and Chris Paul 18 apiece for the Pacific Division leaders, while Durant had 42 points and 10 assists for their North-West Division counterparts, who lost for the second straight game.
The Clippers are three games clear of the Golden State Warriors, with the Phoenix Suns a further half-game back after losing 115-112 to the Houston Rockets. Dwight Howard scored 25 points from just 12 shots while James Harden added 23.
In the Eastern Conference, South-East Division leaders the Miami Heat beat the Chicago Bulls 93-79, despite the absence of LeBron James with a broken nose.
Chris Bosh led the way with 28 points and 10 rebounds while Dwyane Wade added 23 points and 10 rebounds.
Miami's divisional rivals the Washington Wizards also won, 96-83 against the Cleveland Cavaliers.
Deron Williams had 30 points and Paul Pierce 25 as the Brooklyn Nets inflicted a 24th defeat in 30 games on the Los Angeles Lakers by a 108-102 scoreline.
The match also saw Jason Collins become the first openly gay player to appear in any of America's major leagues. The center, who signed a 10-day contract with the Nets earlier in the day, played for a little over 10 minutes as a replacement.
Brooklyn are second in the Atlantic Division behind the Toronto Raptors, who beat the Orland Magic 105-90 with 28 points from Kyle Lowry and 24 from DeMar DeRozan.
Elsewhere, Isaiah Thomas top-scored with 33 points in the Sacramento Kings' 109-95 win over the Denver Nuggets while Damian Lillard's 32 helped the Portland Trail Blazers beat the Minnesota Timberwolves 108-97.