Goals from Marian Hossa and Jonathan Toews earned reigning Stanley Cup holders Chicago the spoils at the Honda Center to keep them clear at the top of the Western Conference Central Division.
However, for Pacific Division pacesetters Anaheim the problems continue, as they were shut out for the second time in three games and have now suffered three successive defeats in regulation time for the first this season.
They have also now lost five of their last seven at home, having previously won 20 of their opening 22 in front of their own fans this season.
Eastern Conference Metropolitan Division leaders Pittsburgh were convincing winners over struggling Buffalo, although they had to come back from a goal down before claiming victory.
Drew Stafford gave the Sabres the lead but Pittsburgh were level by the end of the first period thanks to Harry Zolnierczyk and further goals from Sidney Crosby, Evgeni Malkin, Brian Gibbons and James Neal wrapped up a 5-1 triumph for the Penguins.
In San Jose, a Tommy Wingels strike two minutes into overtime earned the Sharks a 2-1 victory over the Dallas Stars.
Marty Havlat, who assisted on that winning goal, had given San Jose the lead in the second period but Valeri Nichushkin drew Dallas level in the third to send the game to overtime.