Danny Granger top scored for the Pacers with 16 points and three assists with Paul George and Lance Stephenson both weighing in with 15 points each as they recorded their second-straight win, while Arron Afflalo bagged 20 points for Orlando.
Western Conference Pacific Division leaders the Los Angeles Clippers suffered a narrow 116-115 defeat in a high scoring game at the Denver Nuggets.
Randy Foye, with 14 points and four assists, won the game for the Nuggets as time ran down in the fourth quarter.
Nuggets forward Kenneth Faried was their biggest scorer with 28 points and 11 total rebounds.
The San Antonio Spurs remain at the top of the Southwest Division after a 102-95 victory over the New Orleans Pelicans.
Guard Troy Parker was on fire for the Spurs, scoring 32 points and nine assists to inspire the win over the division's bottom side.
In the Eastern Conference, Dwyane Wade scored 30 points and added 10 rebounds as the Miami Heat overcame 21 turnovers to beat the Detroit Pistons 102-96 and cement their position at the top of the Southeast division.
The Portland Trail Blazers lost 100-90 at the Washington Wizards, the Brooklyn Nets got past the Philadelphia 76ers with a 108-102 win and the New York Knicks were defeated 101-98 at the Milwaukee Bucks.
The Chicago Bulls lost their second game on the bounce - a 99-70 loss - against the Sacramento Kings, the Oklahoma City Thunder claimed a 86-77 home victory over the Memphis Grizzlies, while the Dallas Mavericks overcame the Cleveland Cavaliers 124-107 and the Toronto Raptors were 94-79 winners over the Utah Jazz.