The Brooklyn Nets beat the Atlanta Hawks 127-110 in the fourth regular-season game to be played in the capital in as many years, a project kick-started by Stern.
The 71-year-old will walk away at the end of the month after 30 years on the job but Silver fully intends to keep coming back to London.
The current deputy commissioner promised annual regular-season games in the capital remain on the agenda and talked openly about the possibility of the NBA expanding into Europe full-time in the future.
"It's something we've talked about for years, and that is bringing NBA franchises not just to London but to other major European cities as well," he said.
"I think most likely if we were to come to Europe, it would be with a division rather than a single team for ease of logistics and it's something we're going to continue to look at."
For now, the focus will remain on staging individual games and London is at the front of the queue to host them with Stern describing it as "the centre-point" in Europe.
"I think the post-Olympic glow is terrific," Stern said. "And it's been good for basketball."
An economy Stern described as "booming" relative to the rest of Europe helped the NBA sell out this game inside four hours, and that, combined with London's infrastructure, will keep the capital ahead of cities in Europe's more traditional basketball markets such as Spain or Italy.
"The O2 is a spectacular building," Stern added. "The last time we played in Italy I think we played in the Forum. The Forum is as old as me and it looks it.
"These are all considerations, and our sponsors, licensees and international broadcasters, they enjoy coming to the centre-point here in London."
The sell-out crowd enjoyed it too as the Nets maintained their recent hot form by overpowering a Hawks team whose push for a post-season place continues to be hurt by a dismal record on the road.
Joe Johnson had 26 of his 29 points in the first half to power the Nets into a 65-53 lead by half-time and his team-mates took over in the second half, suggesting an expensively-assembled roster might finally be coming together under first-year coach Jason Kidd.
The Hawks might not have been able to keep up, but they kept the crowd entertained all the same, with Mike Scott connecting on Dennis Schroeder's pass for a spectacular alley-oop in the first half.
Veteran Hawks guard Kyle Korver arrived in London having made a three-pointer in each of his last 107 games - easily surpassing the previous NBA record of 89 - and although he missed his first seven attempts he finally sank one with eight minutes remaining to bring the crowd to its feet once more.