Russell Westbrook added 19 points, 12 assists and eight rebounds and Serge Ibaka 19 points and 10 rebounds for his 11th double-double of the season.
Reggie Jackson also scored 19 for Oklahoma City who went to five straight wins and 13 of 14.
The Thunder are unbeaten in 11 home games this season and have won four straight at home over the Lakers.
Los Angeles have lost all three games since the return of Kobe Bryant from a torn Achilles tendon. Bryant had 13 assists - just two shy of his career high - but finished with only four points.
The Detroit Pistons held off a recovery bid from the Brooklyn Nets to wins 103-99 with Andre Drummond posting 22 points and 13 rebounds.
Al Horford scored a season-high 34 points, including a jumper as time expired in overtime, as the Atlanta Hawks beat the Washington Wizards 101-99.
The Boston Celtics beat the New York Knicks 90-86 with Avery Bradley scoring seven of his 13 points in the fourth quarter, hitting a three-pointer with 2:38 to play.
Eric Gordon made 10 of 12 shots on his way to 25 points for the New Orleans Pelicans who won for a second straight game with a 104-98 success against the Memphis Grizzlies.
DeMar DeRozan scored 27 points and Terrence Ross had a season-high 24 as the Toronto Raptors won 108-100 to hand the Philadelphia 76ers a fifth straight loss.
Tony Parker scored 29 points for the San Antonio Spurs who beat the Minnesota Timberwolves 117-110 despite a season-high 42 points from Kevin Love.
Kyrie Irving scored 31 points and Dion Waiters 21 for the Cleveland Cavaliers who beat the Orlando Magic 109-100.
Lance Stephenson had 20 points and 11 rebounds to help the Indiana Pacers improve a franchise-record home start to 11-0 with a 99-94 win over the Charlotte Bobcats.
The Chicago Bulls beat the Milwaukee Bucks 91-90, Utah Jazz won 103-93 against the Denver Nuggets, Phoenix Suns triumphed 116-107 over the Sacramento Kings and the Houston Rockets defeated the Golden State Warriors 116-112.