The Lightning offered a standing ovation and a video tribute to Lecavalier, who spent 14 years with the team, but Victor Hedman scored twice and added an assist to help ensure he finished on the losing side.
Evgeni Malkin chose a good time for his first two-goal game in more than 18 months as he scored in a shoot-out to lift the Pittsburgh Penguins to a 6-5 victory over Toronto.
Sidney Crosby's two assists improved his NHL-best points tally to 33.
Alexander Steen scored his 20th goal of the season as the St Louis Blues overcame the Colorado Avalanche 4-1 while Johan Franzen had three assists in a 6-1 victory for the Detroit Red Wings over the Boston Bruins.
Henrik Lundqvist was back on form with 31 saves as the New York Rangers beat the Florida Panthers 5-2, while Carey Price had 24 as the Montreal Canadiens picked up their fourth straight win, beating the Buffalo Sabres 3-1.
The Carolina Hurricanes scored three in the second period as they beat the New Jersey Devils 4-3 for their first win on the road in seven attempts.
Bobby Ryan scored twice as the Ottawa Senators won 6-4 over the Capitals in Washington, while Al Montoya's 28 saves frustrated the New York Islanders in a 3-2 loss to the Winnipeg Jets.
Rookie goaltender Marek Mazanec secured his second career shutout as the Nashville Predators beat the Columbus Blues Jackets 4-0 while two goals from Radim Vrbata helped the Phoenix Coyotes beat the Minnesota Wild 3-1.
Patrick Kane scored twice and Antti Raanta made 20 saves in his first NHL start as the Chicago Blackhawks beat the Calgary Flames 3-2, while Joe Thornton netted the decisive shootout goal in the eighth round to earn the San Jose Sharks a 3-2 triumph over the Los Angeles Kings.