With Rose on the sidelines and set to have potentially season-ending knee surgery, the Bulls had no answer to the Clippers, who got 16 points and 17 assists from Paul as well as 19 points from JJ Redick.
Chicago's Luol Deng led all scorers with 22 points.
Xavier Henry scored 21 points to lead the Los Angeles Lakers to a 100-86 victory over the Sacramento Kings.
Henry got support from Pau Gasol, who had 20 points and 10 rebounds, and Steve Blake who, with 12 assists, reached had at least 10 dishes for the fifth straight game.
Kevin Durant scored 19 points as the Oklahoma City Thunder remained perfect at home, beating the Utah Jazz 95-73.
The Phoenix Suns beat the Orlando Magic 104-96 and the Detroit Pistons were 109-97 victors over the Brooklyn Nets.