Goals from Daniel Sedin, Zack Kassian, Chris Higgins and Dan Hamhuis and a 21-save shut-out for Roberto Luongo saw Vancouver end their fellow Canadian side's three-game winning streak and celebrate the retirement of former right wing Pavel Bure's number 10 jersey in style.
Alex Killorn had a goal and two assists as Tampa beat the St Louis Blues 4-2 to move top of the division while Detroit hammered the Edmonton Oilers 5-0.
Daniel Alfredsson starred with two assists and both Joakim Andersson and Jakub Kindl had a goal and an assist.
The Pittsburgh Penguins remain seven points clear in the Metropolitan Division after a 3-0 win over the Columbus Blue Jackets.
Deryk Engelland, Chris Kunitz - for the fourth game running - and Jussi Jokinen scored the goals while Jeff Zatkoff recorded a 19-save shut-out in his first NHL win.
Nearest pursuers the New York Islanders won 3-1 at home to the Boston Bruins, Thomas Vanek with a goal and an assist.
The third-placed Washington Capitals beat the Florida Panthers 3-2 after a shoot-out while the New York Rangers beat the Carolina Hurricanes 5-1.
In the Western Conference, the Anaheim Ducks took the lead in the Pacific Division with a 6-3 win over the Buffalo Sabres as previous pace-setters the San Jose Sharks were beaten.
Corey Perry and Emerson Etem scored twice each for the Ducks while Ryan Getzlaf had a goal and two assists.
San Jose lost in a shoot-out to the Phoenix Coyotes, who are a point behind Vancouver in fourth place in the division and only three off Anaheim's lead.
A goal and an assist from Mikkel Boedker earned Phoenix a 2-2 draw in regulation and Antoine Vermette settled the shoot-out 2-1 in their favour.
Central Division pace-setters the Colorado Avalanche and Chicago Blackhawks enjoyed emphatic wins, although the former's 4-1 scoreline against the Montreal Canadiens did not tell the whole story of the game.
The match was level at 1-1 with 12 minutes remaining, before Nathan McKinnon, Ryan O'Reilly and PA Parenteau fired the Avalanche to victory.
Chicago beat the Winnipeg Jets 5-1, Nick Leddy with a goal and an assist and Marcus Kruger two assists.
Elsewhere, the Nashville Predators edged the Los Angeles Kings 4-3 with two goals from David Legwand while the Philadephia Flyers beat the New Jersey Devils 1-0.